Lisinopril — NZ Medication Guide | KiwiMeds
✅ Reviewed by a Registered Pharmacist NZ | Last updated: May 2026 | This information is for educational purposes only and does not replace advice from your doctor or pharmacist.
What is Lisinopril?
Lisinopril is a prescription medicine that belongs to a class called ACE inhibitors (angiotensin-converting enzyme inhibitors). It is one of the most commonly prescribed medicines in New Zealand.
What is it used for?
Lisinopril is used to treat high blood pressure (hypertension), heart failure, and to protect the kidneys in people with diabetes. It is also used after a heart attack to improve survival. It is fully funded by Pharmac for these conditions.
How does it work?
Lisinopril works by blocking ACE — an enzyme that produces angiotensin II, a substance that narrows blood vessels. By blocking this, lisinopril relaxes blood vessels, making it easier for the heart to pump blood and lowering blood pressure.
How to take it
Lisinopril is taken once daily, at the same time each day. It can be taken with or without food. As directed by your doctor — do not stop taking it without medical advice, as your blood pressure may rise again.
Common side effects
Common side effects include a dry, persistent cough (affects up to 20% of people — a well-known side effect of ACE inhibitors), dizziness (especially when standing up), headache, fatigue, and increased potassium levels.
Serious side effects to watch for
Seek urgent medical attention for: sudden swelling of the face, lips, tongue, or throat (angioedema — a rare but serious reaction requiring immediate care), severe dizziness or fainting, signs of kidney problems (decreased urine output), and high potassium levels (muscle weakness, irregular heartbeat).
Important drug interactions
Do not take with potassium supplements or potassium-sparing diuretics without monitoring — risk of dangerously high potassium. NSAIDs (ibuprofen, naproxen) can reduce lisinopril’s effectiveness and increase kidney risk. Avoid other medicines that lower blood pressure simultaneously without guidance.
Things to avoid
Avoid NSAIDs (ibuprofen) — use paracetamol instead for pain relief. Avoid excessive potassium-rich foods (bananas, potatoes) if your potassium is already high. Do not use salt substitutes (many contain potassium chloride). Avoid alcohol as it can enhance blood pressure lowering.
NZ-specific information
Lisinopril is fully funded by Pharmac. The funded brands include Zestril and generics. Blood pressure and kidney function (eGFR) monitoring is recommended. If the cough from lisinopril is troublesome, your doctor may switch you to an ARB (such as losartan or candesartan) which does not cause cough.
Frequently asked questions
Can I take lisinopril if I’m pregnant? No — ACE inhibitors must not be used in pregnancy as they can harm the developing baby. Use effective contraception, and tell your doctor immediately if you become pregnant. Why do I have a cough? This is a common side effect of lisinopril due to accumulation of bradykinin. It is not dangerous but can be very troublesome — talk to your doctor about switching to an ARB.
💬 Always talk to your pharmacist or doctor for advice specific to you. This guide is for general information only and does not replace a professional consultation.
Related medications
Related: Amlodipine, Metoprolol. Condition: Hypertension.
References & Further Information
The following New Zealand and international resources were used to inform this page: