Bupropion — NZ Medication Guide
📋 Reviewed by a Registered Pharmacist NZ — This information is for general educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.
What is Bupropion?
Bupropion is a noradrenaline and dopamine reuptake inhibitor (NDRI) used as an antidepressant and smoking cessation aid. This medication is funded by Pharmac as Zyban® for smoking cessation; antidepressant use requires private purchase.
What is Bupropion Used For?
Used for major depressive disorder (particularly when SSRIs cause sexual dysfunction or weight gain), seasonal affective disorder, and smoking cessation (as Zyban®).
How Does Bupropion Work?
Inhibits neuronal reuptake of noradrenaline and dopamine (minimal serotonin effect). Dopaminergic action underlies both antidepressant effects and reduction of nicotine craving and withdrawal.
How to Take Bupropion
For depression: 150 mg/day in the morning for 3 days, then 150 mg twice daily or 300 mg modified-release once daily. For smoking cessation: start 1–2 weeks before quit date — 150 mg/day for 6 days then 150 mg twice daily for 7–12 weeks. Take in the morning to minimise insomnia.
Common Side Effects of Bupropion
- Insomnia (take in the morning)
- Dry mouth
- Headache
- Nausea
- Dizziness
- Agitation or anxiety (early in treatment)
- Increased sweating
Serious Side Effects — Seek Medical Attention
Contact your doctor or call 111 immediately if you experience any of the following:
- Seizures (dose-dependent — contraindicated in epilepsy and eating disorders)
- Suicidal ideation (as with all antidepressants)
- Hypertension (particularly in patients using NRT for smoking cessation)
- Severe allergic reactions
- Neuropsychiatric effects during smoking cessation
Drug Interactions
Bupropion may interact with other medicines. Always inform your doctor and pharmacist of all medications you are taking. Key interactions include:
- MAOIs (contraindicated)
- Medicines that lower seizure threshold (antipsychotics, theophylline, steroids)
- CYP2D6 substrates (bupropion inhibits CYP2D6 — may increase levels of tamoxifen, codeine, some antidepressants)
- Alcohol (lower seizure threshold)
New Zealand Prescribing Information
Bupropion (Zyban® 150 mg modified-release tablets) is funded by Pharmac as part of the Quitline programme for smoking cessation. As an antidepressant (Wellbutrin® or Zyban®), it is not funded in NZ and must be purchased privately.
Frequently Asked Questions
Does bupropion cause weight gain?
Bupropion is associated with modest weight loss or weight neutrality — unlike most antidepressants. This makes it preferable for patients concerned about weight management.
Is bupropion safe if I have epilepsy?
No — bupropion lowers the seizure threshold dose-dependently and is contraindicated in epilepsy, seizure history, and eating disorders. Discuss your full history with your doctor.
⚠️ Disclaimer: This page is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or a qualified health provider. In New Zealand, medication availability and funding may vary — check with Pharmac or your pharmacist for current information.
Reviewed by a Registered Pharmacist NZ
References & Further Information
The following New Zealand and international resources were used to inform this page: