Calcipotriol — NZ Medication Guide
📋 Reviewed by a Registered Pharmacist NZ — This information is for general educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.
What is Calcipotriol?
Calcipotriol is a synthetic vitamin D3 analogue used topically for the treatment of psoriasis. This medication is funded by Pharmac for psoriasis.
What is Calcipotriol Used For?
Calcipotriol (calcipotriene) is used as a first-line topical treatment for mild to moderate plaque psoriasis. It is often combined with a topical corticosteroid (betamethasone dipropionate) in the combination product Daivobet® for enhanced efficacy.
How Does Calcipotriol Work?
Calcipotriol binds to vitamin D receptors in keratinocytes (skin cells), normalising the abnormally rapid proliferation of skin cells characteristic of psoriasis. It also reduces the production of pro-inflammatory cytokines in psoriatic plaques.
How to Take Calcipotriol
Apply a thin layer to affected plaques once or twice daily (cream or ointment). Maximum 100 g per week for adults. For scalp psoriasis: calcipotriol scalp solution (Daivonex® solution) applied daily. Avoid contact with face and uninvolved skin. Wash hands after application.
Common Side Effects of Calcipotriol
- Skin irritation (stinging, burning, dryness) at application site — very common
- Facial skin irritation if inadvertently applied or transferred to face
- Perilesional erythema
Serious Side Effects — Seek Medical Attention
Contact your doctor or call 111 immediately if you experience any of the following:
- Hypercalcaemia (rare — with large areas of application exceeding 100 g/week)
- Skin atrophy (less than with corticosteroids)
Drug Interactions
Calcipotriol may interact with other medicines. Always inform your doctor and pharmacist of all medications you are taking. Key interactions include:
- Minimal topical interactions
- Systemic hypercalcaemia interactions with oral calcium or vitamin D supplements (only relevant with excessive use)
New Zealand Prescribing Information
Calcipotriol cream, ointment, and scalp solution (Daivonex® and generics) are funded by Pharmac. The combination product calcipotriol/betamethasone dipropionate (Daivobet® gel and ointment) is also funded and is more effective than either agent alone for plaque psoriasis. Maximum weekly dose must not exceed 100 g to avoid hypercalcaemia risk.
Frequently Asked Questions
Can I use calcipotriol on my face for psoriasis?
No — calcipotriol is not recommended for facial psoriasis. It is irritating to facial skin and should be kept away from the face. Facial psoriasis is best managed with weak topical steroids, topical calcineurin inhibitors, or under dermatologist guidance.
How long before calcipotriol improves my psoriasis?
Improvement in plaque psoriasis typically occurs over 4–8 weeks with regular application. Calcipotriol is less likely to cause skin thinning than topical corticosteroids, making it suitable for longer-term maintenance treatment of psoriasis plaques on the body.
⚠️ Disclaimer: This page is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or a qualified health provider. In New Zealand, medication availability and funding may vary — check with Pharmac or your pharmacist for current information.
Reviewed by a Registered Pharmacist NZ
References & Further Information
The following New Zealand and international resources were used to inform this page: