Fexofenadine — NZ Medication Guide
📋 Reviewed by a Registered Pharmacist NZ — This information is for general educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.
What is Fexofenadine?
Fexofenadine is a second-generation, non-sedating antihistamine used for allergic rhinitis and urticaria. This medication is funded by Pharmac and available over-the-counter at NZ pharmacies.
What is Fexofenadine Used For?
Used for seasonal and perennial allergic rhinitis (hay fever) and chronic idiopathic urticaria. One of the least sedating antihistamines available.
How Does Fexofenadine Work?
Selectively blocks peripheral H1 histamine receptors without significant CNS penetration. Unlike terfenadine (its withdrawn parent drug), fexofenadine does not block cardiac potassium channels — eliminating QT prolongation risk.
How to Take Fexofenadine
Adults: 120 mg once daily for allergic rhinitis; 180 mg once daily for urticaria. Take on empty stomach with water only — fruit juices (orange, grapefruit, apple) reduce absorption by up to 36%.
Common Side Effects of Fexofenadine
- Headache
- Nausea
- Dizziness
- Fatigue (minimal sedation — similar to placebo in trials)
Serious Side Effects — Seek Medical Attention
Contact your doctor or call 111 immediately if you experience any of the following:
- Severe allergic reaction (very rare)
Drug Interactions
Fexofenadine may interact with other medicines. Always inform your doctor and pharmacist of all medications you are taking. Key interactions include:
- Fruit juices (reduce absorption significantly — take with water only)
- Antacids with aluminium/magnesium (reduce absorption — separate by 2 hours)
New Zealand Prescribing Information
Fexofenadine (120 mg and 180 mg tablets — Telfast® and generics) is funded by Pharmac and available OTC in NZ. It is among the least sedating antihistamines. The interaction with fruit juices is clinically significant — always take with water.
Frequently Asked Questions
Why should I not take fexofenadine with fruit juice?
Orange, grapefruit, and apple juices block the OATP gut transporters that absorb fexofenadine, reducing absorption by up to 36%. Always take with plain water to ensure full efficacy.
Is fexofenadine completely non-drowsy?
Fexofenadine is among the least sedating antihistamines — clinical trials show drowsiness rates similar to placebo. Most patients can take it safely before driving.
References & Further Information
The following New Zealand and international resources were used to inform this page:
- New Zealand Formulary — Fexofenadine
- Pharmac — Funded Medicines Schedule
- BPAC NZ — Allergic Rhinitis
⚠️ Disclaimer: This page is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or a qualified health provider. In New Zealand, medication availability and funding may vary — check with Pharmac or your pharmacist for current information.
Reviewed by a Registered Pharmacist NZ