Clopidogrel — Blood Clot Prevention Guide | KiwiMeds
✅ Reviewed by a Registered Pharmacist NZ | Last updated: May 2026 | This information is for educational purposes only and does not replace advice from your doctor or pharmacist.
What is clopidogrel?
Clopidogrel is an antiplatelet medicine that prevents blood clots from forming. It is commonly used after a heart attack, stroke, or the placement of a coronary stent. In New Zealand it is available as a generic and under the brand name Plavix.
What is it used for? (NZ context)
Clopidogrel is used to prevent heart attacks and strokes in people who have already had one, or who have peripheral arterial disease or coronary artery disease. It is also used after stents are placed in arteries. Clopidogrel is funded by Pharmac with Special Authority criteria.
How does it work?
Clopidogrel blocks the ADP receptor on platelets, preventing them from clumping together. Platelets are cells in the blood that stick together to form clots. By keeping them less “sticky”, clopidogrel reduces the risk of dangerous blood clots forming in arteries.
How to take it
Clopidogrel is usually taken once daily, with or without food. Never stop taking clopidogrel without talking to your doctor first — stopping suddenly (especially after a stent) can trigger a serious clot. Always carry a card noting you are on an antiplatelet medicine.
Common side effects
- Easy bruising
- Bleeding that takes longer to stop
- Upset stomach or indigestion
- Headache
Serious side effects to watch for
Seek urgent medical help if you notice unusual or excessive bleeding, blood in urine or stools, severe headache, or signs of an allergic reaction. Tell all healthcare providers you are taking clopidogrel before any surgery or dental procedure.
Important drug interactions
Aspirin is commonly combined with clopidogrel (dual antiplatelet therapy) — this is often intentional but increases bleeding risk. Proton pump inhibitors (especially omeprazole) may reduce clopidogrel’s effectiveness; pantoprazole is preferred if a PPI is needed. NSAIDs such as ibuprofen increase bleeding risk.
NZ-specific information
Pharmac funding: Clopidogrel is funded by Pharmac under Special Authority for people with acute coronary syndromes, peripheral arterial disease, or stent placement. Generic clopidogrel 75mg is the funded form. Brand name: Plavix.
Frequently asked questions
Do I need to stop clopidogrel before surgery?
Usually yes — most surgeons ask you to stop clopidogrel 5–7 days before surgery to reduce bleeding risk. But never stop it without medical advice, especially if you have a stent.
Can I take ibuprofen with clopidogrel?
Ibuprofen and other NSAIDs increase the risk of bleeding when taken with clopidogrel. Paracetamol is a safer pain relief option. Talk to your pharmacist before taking any over-the-counter pain medicines.
What’s the difference between clopidogrel and aspirin?
Both prevent clots but by different mechanisms. Aspirin blocks thromboxane, while clopidogrel blocks ADP receptors. They are often used together after a heart attack or stent.
💬 Talk to your pharmacist or doctor for personalised advice about clopidogrel.
Reviewed by a Registered Pharmacist NZ | BPharm, Pharmacy Council of New Zealand
References & Further Information
The following New Zealand and international resources were used to inform this page: