Loratadine — NZ Medication Guide
📋 Reviewed by a Registered Pharmacist NZ — This information is for general educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.
What is Loratadine?
Loratadine is a second-generation, non-sedating antihistamine used for allergic rhinitis and urticaria. This medication is funded by Pharmac and available over-the-counter at NZ pharmacies.
What is Loratadine Used For?
Loratadine is used for allergic rhinitis (hay fever), chronic idiopathic urticaria, and other allergic conditions in adults and children. Its low sedation profile makes it particularly suitable for patients who need to remain alert.
How Does Loratadine Work?
Loratadine is a selective peripheral H1 antihistamine with very limited CNS penetration due to its inability to cross the blood-brain barrier effectively. This selectivity provides antiallergic efficacy with minimal sedation compared to first-generation antihistamines.
How to Take Loratadine
Adults and children over 12 years: 10 mg once daily. Children 2–12 years: 5 mg/day (if <30 kg) or 10 mg/day (if ≥30 kg). Can be taken with or without food. Loratadine does not require dose adjustment for renal or hepatic impairment at standard doses.
Common Side Effects of Loratadine
- Headache
- Dry mouth
- Drowsiness (minimal — significantly less than cetirizine and first-generation antihistamines)
- Fatigue
Serious Side Effects — Seek Medical Attention
Contact your doctor or call 111 immediately if you experience any of the following:
- Severe allergic reaction (very rare)
Drug Interactions
Loratadine may interact with other medicines. Always inform your doctor and pharmacist of all medications you are taking. Key interactions include:
- CYP3A4 inhibitors (ketoconazole, erythromycin — may increase loratadine levels — generally well tolerated)
- Alcohol (minimal interaction — but caution with CNS impairment)
New Zealand Prescribing Information
Loratadine (10 mg tablets; 5 mg/5 mL syrup — Claratyne® and generics) is funded by Pharmac and widely available OTC in NZ. It is among the preferred second-generation antihistamines for patients who need to drive or operate machinery and for use in daytime. Desloratadine (the active metabolite, Neoclarityn®) is also available but not funded.
Frequently Asked Questions
What is the difference between loratadine and cetirizine?
Both are second-generation antihistamines with similar efficacy for hay fever and hives. Loratadine has a lower risk of sedation — making it preferable when alertness is important (e.g., driving). Cetirizine may be slightly more effective for some patients but has a higher sedation rate. Individual responses vary.
Can I take loratadine and a decongestant together?
Yes — loratadine/pseudoephedrine combination products are available (Claratyne-D®) for hay fever with nasal congestion. However, decongestants can raise blood pressure and heart rate — avoid in patients with hypertension, heart disease, or hyperthyroidism.
References & Further Information
The following New Zealand and international resources were used to inform this page. We encourage you to consult these authoritative sources for the most current information:
⚠️ Disclaimer: This page is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or a qualified health provider. In New Zealand, medication availability and funding may vary — check with Pharmac or your pharmacist for current information.
Reviewed by a Registered Pharmacist NZ