Sucralfate — NZ Medication Guide
📋 Reviewed by a Registered Pharmacist NZ — This information is for general educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.
What is Sucralfate?
Sucralfate is a mucosal protective agent used for peptic ulcer disease and gastro-oesophageal reflux. This medication is funded by Pharmac for peptic ulcer disease.
What is Sucralfate Used For?
Sucralfate is used for the treatment and prevention of peptic ulcers (gastric and duodenal), stress ulcer prevention in critically ill patients, and oesophageal ulceration. It may also be used for radiation-induced proctitis.
How Does Sucralfate Work?
Sucralfate is an aluminium salt of sucrose octasulphate. In the acid environment of the stomach, it polymerises and adheres to ulcer craters and damaged mucosa, forming a protective barrier against acid, pepsin, and bile. It also stimulates prostaglandin and mucus production.
How to Take Sucralfate
Taken on an empty stomach, 30–60 minutes before meals and at bedtime (4 times daily), or twice daily for maintenance. Swallow tablets whole (or as a suspension), with a full glass of water. Separate from other medicines by at least 2 hours as sucralfate can reduce their absorption.
Common Side Effects of Sucralfate
- Constipation (most common side effect)
- Dry mouth
- Nausea
- Indigestion
- Rash (rare)
Serious Side Effects — Seek Medical Attention
Contact your doctor or call 111 immediately if you experience any of the following:
- Aluminium accumulation (with prolonged use in renal impairment — encephalopathy risk)
- Bezoar formation (rare — mainly with high doses and poor motility)
Drug Interactions
Sucralfate may interact with other medicines. Always inform your doctor and pharmacist of all medications you are taking. Key interactions include:
- Many medicines: sucralfate reduces absorption of fluoroquinolones, tetracyclines, digoxin, warfarin, phenytoin, levothyroxine, PPIs, and many others — take all other medicines at least 2 hours before sucralfate
New Zealand Prescribing Information
Sucralfate (1 g tablets; 1 g/5 mL suspension — Antepsin®) is funded by Pharmac. Because sucralfate works in an acidic environment, it should not be taken simultaneously with PPIs or H2 blockers (which raise gastric pH). Sucralfate is a useful option for patients who require mucosal protection without systemically absorbed medicine — particularly for stress ulcer prevention and in renal impairment where PPIs may be a concern.
Frequently Asked Questions
Can I take sucralfate with my other medicines?
Sucralfate significantly reduces the absorption of many medicines including antibiotics, digoxin, warfarin, thyroid medicines, and PPIs. You should take all other medicines at least 2 hours before sucralfate. Always inform your pharmacist you are taking sucralfate when having any new medicine dispensed.
Does sucralfate need to be taken on an empty stomach?
Yes — sucralfate works best when taken 30–60 minutes before meals on an empty stomach. This allows it to polymerise and form a protective coat on the stomach lining before food and acid stimulate the mucosa.
⚠️ Disclaimer: This page is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or a qualified health provider. In New Zealand, medication availability and funding may vary — check with Pharmac or your pharmacist for current information.
Reviewed by a Registered Pharmacist NZ
References & Further Information
The following New Zealand and international resources were used to inform this page: