Pregabalin — NZ Medication Guide
📋 Reviewed by a Registered Pharmacist NZ — This information is for general educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.
What is Pregabalin?
Pregabalin is an anticonvulsant and analgesic used for neuropathic pain, epilepsy, and generalised anxiety disorder. This medication is funded by Pharmac under Special Authority for neuropathic pain and focal epilepsy.
What is Pregabalin Used For?
Used for peripheral and central neuropathic pain (diabetic neuropathy, post-herpetic neuralgia), focal seizures, and generalised anxiety disorder (GAD).
How Does Pregabalin Work?
Binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing release of excitatory neurotransmitters (glutamate, noradrenaline, substance P) in pain and epilepsy pathways.
How to Take Pregabalin
Taken two to three times daily. Start 75 mg twice daily and titrate to max 600 mg/day. Reduce dose in renal impairment. Taper gradually when stopping — do not stop suddenly.
Common Side Effects of Pregabalin
- Dizziness (very common)
- Drowsiness and sedation
- Weight gain
- Peripheral oedema (ankle swelling)
- Blurred vision
- Dry mouth
- Impaired concentration or memory
Serious Side Effects — Seek Medical Attention
Contact your doctor or call 111 immediately if you experience any of the following:
- Respiratory depression (particularly with opioids — potentially fatal)
- Suicidal ideation (all antiepileptics — monitor mood)
- Dependence and withdrawal
- Severe allergic reaction
Drug Interactions
Pregabalin may interact with other medicines. Always inform your doctor and pharmacist of all medications you are taking. Key interactions include:
- Opioids (respiratory depression — significant risk)
- Benzodiazepines (additive sedation and respiratory depression)
- Alcohol (additive CNS depression)
- Thiazolidinediones (increased oedema risk)
New Zealand Prescribing Information
Pregabalin (75 mg, 150 mg, 300 mg capsules — Lyrica® and generics) is funded under Special Authority. It is a Class C controlled substance in NZ due to significant misuse potential. Prescribers should screen for abuse risk.
Frequently Asked Questions
Is pregabalin addictive?
Pregabalin can cause physical dependence and has been misused — particularly at high doses or combined with opioids. Do not stop suddenly; taper slowly under medical supervision.
Can pregabalin be combined with opioids?
This combination significantly increases respiratory depression risk. Use the lowest effective doses of each and review regularly — it requires careful medical supervision.
⚠️ Disclaimer: This page is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or a qualified health provider. In New Zealand, medication availability and funding may vary — check with Pharmac or your pharmacist for current information.
Reviewed by a Registered Pharmacist NZ
References & Further Information
The following New Zealand and international resources were used to inform this page: